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intraoperative radiation therapy : ウィキペディア英語版 | intraoperative radiation therapy
Intraoperative radiation therapy, or IORT is the application of therapeutic levels of radiation to the tumor bed while the area is exposed during surgery. IORT is typically a component in the multidisciplinary treatment of locally advanced and recurrent cancer, in combination with external beam radiation, surgery and chemotherapy. As a growing trend in recent years, IORT can also be used in earlier stage cancers such as prostate and breast cancer. == Applications == The goal of IORT is to improve local tumor control and survival rates for patients with different types of cancer. Targeted intraoperative radiotherapy is a technique developed since 1998 for treatment of the tumour bed after wide local excision (lumpectomy) of breast cancer. The 5-year results of the TARGIT-A trial, which recruited 3451 patients, were presented at 2012 San Antonio Breast Cancer Conference and show that giving TARGIT at the time of lumpectomy in ER+ PR+ patients, aged 45 years and over, gives results similar to whole breast radiotherapy in terms of local cancer control, with fewer non-breast cancer deaths and a trend for lower overall mortality. (2012 SABCS, Thursday 6 December, General Session 4 ). These 5-year results equivalent to several weeks of whole breast radiation therapy, were published in (the Lancet )
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